Djokovic stole the show in a straight sets win, claiming his sixth Australian Open title, an equal record with Roy Emerson.
The dominant Serb also extended his Grand Slam winning streak to 21 matches, and has not lost a match at the majors since he was defeated by Stan Wawrinka in last year's French Open final at Roland Garros.
In a classy post-match speech to the crowd at Rod Laver Arena, Murray thanked nearly everyone in the building, and fought back tears while talking about his wife. The first one out of here, I'm leaving.
Another overpowering Australian Open win kept him head and shoulders above his peers, but Novak Djokovic said fears of a "big slap from karma" make him humble as he continues his quest for Grand Slam history. I've been held on flights for it feels like five days.
From Serena Williams' surprise upset, to Novak Djokovic's regular opponent-trampling; from #HewBeauty to #TennisFixing, Australian Open 2016 was in the news for more than a few reasons.
The Scot was blown away in the first set as the world number one needed just 32 minutes to win the opener 6-1. "For the first time in as long as I can remember, the same player is the favourite at all four Majors", the American told USA Today.
There was no telling early that the final would be such a one-sided affair as Murray pressed hard to conjure a break point in the opening game of the match.
Now 28, Djokovic has joined greats Bjorn Borg and Rod Laver on 11 major titles, behind only Roy Emerson (12), Rafael Nadal and Pete Sampras (14 each), and, of course, Federer.
Second seed Murray, 28, has now lost all five Australian Open finals he has played, four of them against Djokovic.
Murray, before making a dash to the airport to fly home to his pregnant wife, said he felt he remained in touch with Djokovic despite their widening head-to-head statistics. The timing is also not on Murray's side, with Djokovic getting an extra day of rest after his four-set defeat of Roger Federer in Thursday's semifinal. "I started the last couple of matches quite slowly, [which is] understandable in some respects, I think".
"I was able to get myself into the net more".
Djokovic improved to a 22-9 record against Murray as he wrapped up victory in two hours and 53 minutes.
"No doubt I am playing the tennis of my life the last 15 months and the results are showing that". The set had all the makings of heading into a tiebreaker, but Murray blew a 40-0 lead on his serve in the 11th game, as Djokovic came back to get the decisive break and a 6-5 lead.