It was a win which came after a dispiriting run at the Slams - a shock semi-final defeat to Roberta Vinci in NY 12 months ago followed by losses in the Australian and French Open finals to Angelique Kerber and Garbine Muguruza respectively.
Even if Djokovic manages to fully recover physically, questions remain about his mental state given the 29-year-old's admission that "private issues" lurked in the background of his Wimbledon exit. "I will try and compensate and improvise as much as I can and find the best ways of getting myself properly treated", he explained.
Djokovic, who completed a career grand slam earlier this year by winning the French Open, has been undergoing "electricity treatments", and the injury means he might have difficulty executing his backhand shots.
Both those tournaments saw world no. 1 Novak Djokovic knocked out earlier than expected, and Murray may not be so lucky this time round.
"Tennis isn't the most important thing in my life anymore", Murray said.
"I got injured, but before the injury I was third in the race (for the Tour finals) and not very far from No. 2".
"That was the period for me".
Djokovic said the reasons for his All England Club catastrophe were not physical but private. Life is going on'.
But despite the ups and downs, Djokovic said the Wimbledon loss may work in his favour.
But Murray, the reigning Wimbledon and Olympic champion, insists that the bad blood is a thing of the past and will not impact their opening round meeting at Flushing Meadows next week.
Robson is not the only player to be recovering from a wrist injury in NY after Novak Djokovic admitted he is struggling for fitness ahead of his title defence.
"I have not played a lot, I haven't practised a lot, but I'm just now starting to feel a little better", Williams said.
"I have actually gotten along fine with him apart from that day".
Djokovic, who has played in six of the last nine US Open finals and is the defending champion, remains the bookmakers' favourite to win the tournament, which begins here on Monday, despite having to deal with an injury to his left wrist which forced him to pull out of last week's Cincinnati Masters.
"The third-round loss at Wimbledon to Sam allowed me to take some time and really regroup and think about what was achieved with the French Open", the Serb said. After that, it took a bit of time for me to get centred again. I know she's a good player. Hopefully that's going to be the case next couple days.
Having won the Canadian Open, Djokovic then lost in the first round of the Olympics against Juan Martin del Potro.