"The Zionist regime (Israel) poses the biggest threat to regional and worldwide peace and security by possessing hundreds of nuclear warheads in its arsenal", Foreign Ministry spokesman Bahram Qasemi was quoted as saying by the semi-official Tasnim news agency.
"The security challenges faced by Israel are enormous, including the threat of Iran's nuclear ambitions, which I've talked a lot about", Trump said.
On Wednesday, the new US president assured the visiting Israeli premier that he would not allow Iran to develop nuclear weapon to pose security challenges to Israel; and he once against referred to the Iranian nuclear deal as "the worst deal ever".
The recent anti-Iran remarks by US President Donald Trump and Israel's Benjamin Netanyahu contain nothing except a repetition of bogus and unworthy allegations against Iran's peaceful nuclear program, Bahram Qassemi said on Thursday.
"The bitter truth is that these unjust claims are being repeated by the Zionist regime that doesn't abide by any global laws and has hundreds of warheads in its atomic arsenal", Ghasemi said, referring to Israel.
Israel, believed to have the Middle East's only nuclear arsenal with 200 warheads, sees Iran's nuclear programme as a threat to its existence.
But Ghasemi dismissed the comments by Trump and Netanyahu comments as "nonsense".
Under the agreement, Iran suspended and dismantled a large part of its nuclear program in exchange for the lifting of many - but not all - sanctions against the country.
Iran and six major world powers reached an agreement on the former's disputed nuclear program in July 2015, which was implemented in January past year.
Iran conducted another ballistic missile earlier this month prompting the Trump administration into imposing new economic sanctions against Iran.