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Speaking prior to the clash, Ferdinand was surprised Carrick was not in action.
Mourinho has never lost a competitive match to Wenger, but says he does not have the resources to defend that record.
According to Mourinho, he will be resting key players to focus on the Europa League, which continues at midweek after United put down Celta Vigo in the first leg by a score of 1-0.
"They've got goals in there, backed up by Pogba".
Speaking after Thursday night's Europa League semi-final victory over Celta Vigo, Mourinho informed fans that he will rest certain players this weekend.
He was adamant Arsenal would not shift their summer transfer targets if they failed to make the Champions League and claimed he would follow Mourinho in taking the Europa League seriously.
Juan Mata, who has been absent for the last six weeks with a groin problem, is also fit although Mourinho said the Spaniard was not ready to play 90 minutes.
However, the fresh concerns to Rashford and Young are the last thing Mourinho needed as they could now join Zlatan Ibrahimovic, Marcos Rojo, Luke Shaw and Timothy Fosu-Mensah in missing the Arsenal game.
Arsenal will be without midfielder Granit Xhaka, ruled out with an ankle injury sustained in last week's North London derby defeat, and Lucas Perez who picked up an injury in training this week - but centre-back Shkodran Mustafi is back in contention for the Premier League fixture. "I'm open always in life for everything, for peace, but what is important when you are a competitor is that you give everything to win the next game", the 67-year-old Frenchman added. Both sides are in need of a win in order to keep their top-four hopes alive.
Manchester United boss Jose Mourinho has revealed that he could one day return to manage in Italy and admitted a return to Inter remains possible. If Celta was playing with their best team, if Celta was fighting for important things in La Liga, we would go in the same circumstances, but I can not now play with the same team that played here, and then repeat again on the next Thursday.
With Chelsea clear at the top and Tottenham well-placed in second, Liverpool (69 points, 35 games), City (66, 34), United (65, 34) and Arsenal (60, 33) are looking to finish behind them.