Iran repeated accusations that Saudi Arabia funds Islamic militants including Islamic State.
Khamenei said Iran had no intention of normalizing ties with the United States.
"In the event that America wages a war against Iran, all of that country's military bases in the region will be in danger, as Iran is capable of hitting targets with its missiles within a range of 2,000 kilometers", Major General Yahya Rahim Safavi said on Wednesday.
Izadi, however, did not present any tangible proof to support the claims.
The deal has failed to normalize relations with the nations.
U.S. President Donald Trump promised to impose harsh terms on Iran, indicating he will reverse the Obama Administration's attempts at rapprochement with Tehran. Trump has frequently called the agreement "one of the worst deals ever signed" and said Washington would review it.
The pragmatist president championed a nuclear deal with the United States and five other powers in 2015 that led to the lifting of most sanctions against Iran, in return for curbs on its nuclear programme.
His comments come just after jihadis armed with guns and suicide bombs attacked the Iranian Parliament in the capital city of Tehran, killing 17.
While acknowledging that the stance of the current White House administration on the deal's future "is not very promising", Jarif argued that since the deal involves several parties, they will not let the USA sabotage what took their common efforts to seal. The attack was claimed by Islamic State militants via its news agency Amaq.
"Some of the problems with the USA are essentially unresolvable, as the U.S.'s problem with us has nothing to do with nuclear energy or human rights, their problem is with the principle of the Islamic Republic", he added.
From January to March 2017 "we dismantled 45 cells, while in the past two-and-a-half months alone we have dismantled more than 25 terrorist cells", he said.
Commenting on the statement at the time, Zarif called it "repugnant" and slammed a new round of U.S. sanctions against Iran recently approved by Senate.