City are this season's front-runners, and with good reason.
David Luiz is still suspended and there are suggestions that Chelsea's top scorer, Alvaro Morata, could also miss out through injury after picking up a knock during Wednesday's fixture.
The second month of the Premier League season ends this weekend with one of the most anticipated matches of the entire season: Chelsea vs.
"Honestly, I'm not anxious because I think I have players that try to make the best decision and it's important to understand when there is the room to travel, to go to see a game or for other situations", Conte said in his pre-match press conference.
However, Luiz played in midfield that day, but is likely to continue in his usual position as the deepest centre-back.
The Citizens have started the season in incredible form and Pep Guardiola's side is arguably the most exciting team to watch in world football right now. In fact, Guardiola's side has won nine of its last ten games while keeping clean sheets in five of the last seven Premier League matches. We'll go there and play the way we'd have done it with Sergio, Kompany, Mendy.
Elsewhere, Wayne Bridge - who represented both sides - has tipped City for title success. With Leroy Sané and Raheem Sterling coming off the bench to score in nearly every game as well, the Citizens' squad depth is frightening, and it is no surprise that they have won all of their away games in the league so far.
Manchester City's last three league matches may have seen City score 16 unanswered goals, but Chelsea present a far tougher proposition than Crystal Palace (thrashed 5-0 last week) and Watford (6-0 the week before that).
"Manchester City have definitely improved their squad significantly, particularly in terms of their defence".
"If City could get a win it would be incredible", he said, "and it would be a massive statement to the rest of the league". City will already have played two of the supposed big guns in Liverpool and Chelsea with United yet to have played any of their rivals. The big clubs do it - they overcome the hard situations. The Blues dominated many games last season but wastefulness was costly and meant they fell short of challenging for the title.
The Blues will come in the game on the back of a couple of very impressive results.