President Petro Poroshenko underscored the seriousness of the situation by telling his top military brass and Prime Minister Volodymyr Groysman to report to him directly after visiting the site.
"Steps to localize the fire in the arsenal of the Armed Forces of Ukraine in Vinnytsia region continue, the hot spots are being and extinguish on the territory of the arsenal", reads a report on its Facebook page posted on Wednesday morning.
Police spokesman Yaroslav Trakalo said the fire had caused artillery shells at the facility to explode one after the other, news outlet Pravda said on its website. Kiev and many Western countries accuse Moscow of supporting the insurgents, which Russian Federation vehemently denies. Local authorities said they had ordered the evacuation of Kalynivka and two neighbouring villages, while urging people not to panic.
This is reported by the press service of the State Emergency Service of Ukraine.
The extent of the damage was not clear but local media described the depot as one of the country's largest.
As reported, at around 22:00 on September 26, reports arrived about explosions of ammunition in an arsenal of the Defense Ministry near the town of Kalynivka (Vinnytsia region).
Police cordoned off roads as residents fled their homes and Ukrainian authorities also closed off the airspace within a 50km radius of the city.
The Ukraine has been fighting Russia-backed separatists since April 2014.