One of the incidents that led to Weinstein's self-banishment to a European sex-addiction clinic was recounted by the victim actress to MacFarlane, creator of "Family Guy", who daringly joked about it while hosting the Academy Awards ceremony, Entertainment Weekly reported.
In his Wednesday tweet, MacFarlane claimed that Barth confided in him about Weinstein's alleged harassment in 2011, which informed his controversial Oscars dig at Weinstein; "It was with this account in mind that, when I hosted the Oscars in 2013, I couldn't resist the opportunity to take a hard swing in his direction", he said.
"She has since courageously come forward to speak out", MacFarlane added.
In recent days, the joke has been seen to take on new meaning as shocking stories have come to light regarding Weinstein's gross treatment of women. Seth - who has joined the likes of Meryl Streep, Angelina Jolie and Gwyneth Paltrow in criticising Weinstein - praised the actress for having the courage to come forward. Especially when it involves a famous person, thousands of people automatically don't believe you because they assume you are just doing it for a settlement or are trying to get famous or think you for some reason were "asking for it". "I respect and applaud my friend Jessica and those sharing their stories for their decision to come forward, and for being champions of the truth". But certainly it assumes a much haunting nuance now, in the face of dozens of allegations of sexual harassment, assault, and rape.
Ms Barth has responded to criticism of Mr MacFarlane for not speaking up at the time.
Unwanted advances by Weinstein were also referenced in a 2012 episode of "30 Rock", in which an actress played by Jane Krakowski said, "I'm not afraid of anyone in show business".
He has been fired from his job at The Weinstein Company and his wife Georgina Chapman has confirmed she has left the producer.