Recently-crowned FedEx Cup victor Justin Thomas and Rickie Fowler overcame South African pair Louis Oosthuizen and Branden Grace 3 and 2, but with the three remaining contests close at that stage the global side would have harboured hopes of reducing the deficit.
Phil has won 2.5 points for Team USA thus far in this Cup, bringing his tally to 25 career wins in the Presidents Cup.
The latter duo were ahead through two holes thanks to a birdie at the par-five second, but their opponents won five of the next seven to lead four-up at the turn.
"These guys are trying their arses off", Price said.
"We're not going to lay down".
Where the USA team appears to be forging a foundation for future competitions, Price's worldwide side continues to be mired in a jigsaw puzzle of divergent personalities and cultures that just doesn't fit together.
"I think we saw the strength of the United States team come out, but in all fairness to my guys, I don't think they played as well as they were capable of". We're now seeing why the Americans were such heavy favorites, as they've completely overmatched the Internationals in both formats over two days. The magic number for one team to secure a victory is 15.5 points.
Tomorrow's third day sees four foursomes matches in the morning and four fourballs in the afternoon with 12 singles matches to be played Sunday.
"We try to beat each other that day, " Spieth said.
"It is a great honor for me to be even a small part of the Presidents Cup", said Trump when his honorary role was announced in July.
"It's a challenge, but we're used to playing in winds like this", Reed said. Koepka hit his tee shot on the par-3 10th to 12 feet and made the birdie to give his team its first lead of the match, and Johnson got up-and-down on the reachable par-4 12th for a 2-up lead. But this team I think is better still thank that.
US captain Steve Stricker sent out British Open champion Spieth and Reed first and the high energy duo set the American pace at a breezy Liberty National winning four straight holes from the 12th to collect a 4&3 win over Australian duo of Jason Day and Marc Leishman.