Speaking at St George's Park, Burton, ahead of the clash with the world champions at Wembley on Friday night, Southgate was sure that all six withdrawals were genuine and was keen to focus on the positives of other players getting their chance to shine. It's their livelihood, it's their career.
So depleted is Southgate's squad that he has been forced to borrow youngsters from England's junior teams in training.
"We have attacking players like Timo Werner, Julian Draxler or Leroy Sane - they are different players".
"We want to make a good game, the result is always important".
'The players are injured and can not play, ' Southgate told BBC Radio 5 live.
He doesn't care if that comes at the expense of some high-profile stars and he said: "I care for the players".
Harry Winks and Fabian Delph also failed to report due to injury while Danny Drinkwater declined a call-up on fitness grounds, meaning that 21-year-old Ruben Loftus-Cheek, who is on loan at Crystal Palace from Chelsea, is in line to make his debut against Germany. "With the tournament in mind I want to see not only those players who play regularly".
Gareth Southgate has admitted England's set-up is not at the same stage as Germany's, and said it will take time for players from the youth teams to break into the senior side.
"He has played at every level for England previously. A really great moment for him".
The midfielder has been called into the England squad for their two friendlies with Germany and Brazil over the next few days after a host of Three Lions regulars pulled out with injury problems.
Yet Southgate is "phlegmatic" about ending 2017 with such a depleted squad and will not be moving away from a three-man defence because of it.