The broader NSE Nifty too slipped by 9.50 points, or 0.09%, to end at 10,118.25, after moving between 10,069.10 and 10,147.95. Sustained buying in the trade on Thursday trade provided cushion to the indices that eventually led to both the Sensex and Nifty wrapping up the session with gains of over 1%.
The gauge had rallied 352.03 points Thursday.
On Friday, the benchmark indices were dragged lower by growing concerns over the country's widening fiscal deficit, coupled with negative global cues and profit booking in auto, metal and oil and gas stocks.
Other losers included Tata Steel, NTPC, Dr Reddy's, ONGC, Power Grid, Bajaj Auto, L&T, M&M, Asian Paints, HDFC Bank, HUL, Lupin, Coal India, ITC, Tata Motors, Axis Bank, Maruti Suzuki and Infosys, falling by up to 1.71 per cent.
Shares of Biocon surged 15% after the biotechnology major said it has received regulatory approval to market a biosimilar of cancer drug Herceptin in the US.
Among the Sensex constituents, telecom giant Bharti Airtel secured podium finish, ratcheting up 6.08%.
The NSE Nifty50 fell by 74.15 points or 0.73 per cent to close at 10,044.10 points, while the Sensex at 32,597.18 points - down 205.26 points or 0.63 per cent. Shanghai Composite, however, shed 0.08%.
Japan's Nikkei 225 was trading in green, up by 1.14 per cent, Hang Seng up by 0.94 per cent while South Korea's Kospi was up by 0.26 per cent.
The US Dow Jones Industrial Average ended 0.29 per cent higher in yesterday's trade.