Kyle Anderson played well as the replacement, before injuring his left knee during Sunday's game.
LaMarcus Aldridge's 17 points led a balanced attack for the Spurs, who had three starters record double-doubles and seven players score in double-figures.
In 23 games this season, Anderson is averaging 8.9 points, 6.0 rebounds, 3.0 assists and 1.2 steals in a little over 27 minutes a game. His final points came on a three-point play that gave San Antonio an 88-86 lead with 3:39 remaining.
NOTES: San Antonio F Kawhi Leonard, who has not played this season because of a quad injury, met with the media on Monday for the first time since late September but had no specific update on his rehabilitation or when he might return to game action. If not those two games, then San Antonio won't play at home until Saturday, Dec. 16.
Detroit trailed 94-93 when Gay failed to hit the rim on a 3-point attempt as the shot clock expired with 5.2 seconds remaining, but the Pistons' Tobias Harris committed a foul prior to the violation. They've been playing good basketball in the East and they are one of top teams in the East. Detroit has lost three straight to fall to 14-and-9.
Will Leonard be back for Wednesday's game vs. the Miami Heat?
The Spurs are listing forward Rudy Gay (sore right heel) and big man Joffrey Lauvergne (right middle finger) as probable. Manu Ginobili had 12 points, and Danny Green, Patty Mills and Davis Bertans each finished with 11. "Everybody gets injuries. You've just got to deal with it", he continued.
The Spurs had announced earlier in the day Anderson would miss Monday night's game against the Detroit Pistons at the AT&T Center.