Pogba's absence may impact Mourinho's game plan for the derby, given the United boss bemoaned the midfielder's absence following an insipid goalless draw against Liverpool at Anfield earlier this season, but De Bruyne is unsure exactly which way the Red Devils will play.
"You can not work on that", De Bruyne said.
The France worldwide was sent off for a challenge on Hector Bellerin in the 74th minute of United's 3-1 victory at the Emirates Stadium. "It's a competition, you want to play against the best teams and the best players".
The Portuguese tactican was very happy with his own players performance on the night describing it as "amazing, phenomenal, fantastic", and was especially happy with goalkeeper David De Gea's performance saying that "that what I saw today was the best goalkeeper in the world".
GETTY Paul Pogba will miss the Manchester derby after seeing red in the win over Arsenal
With Manchester City still eight points clear of derby rivals United ahead of their critical match this weekend, it's natural that the red half of the city are looking for every advantage possible to keep them in the title race.
BetStars spokesman Ian Marmion said: "Kevin De Bruyne has taken the Premier League by storm this season, tallying four goals and seven assists in the league already this season, which has inevitably attracted the attention of Europe's elite clubs".
"United are one of the biggest clubs in the country".
"But the way we try to play is the same, we put them under pressure. You're leading 3-1, you're protecting a lead and you understand the importance of the game and I think it's affected his approach to the tackle". It's a busy two months when things can change but the way we're going is good and we need to continue that.