The trip was made possible thanks to a pastor in NY who organised the trip.
After connecting through the online game, Spencer said he and Roz had played more than 300 matches together.
A young man and an elderly woman who "randomly" met playing Words With Friends together online a year ago and went on to share 324 games have now met up in person.
Spencer, 22, lives in Harlem.
Words With Friends also called the story "amazing" on Twitter.
At least one Twitter user who responded had a similar story, pointing to the ability of the game that was developed in 2009 by social game developer Zynga to bring word enthusiasts together over miles of coastline or even oceans. "So last summer i randomly met this 80 y/o woman on words with friends". And finally, last week, the unlikely duo got to meet in person in Florida after a pastor coordinated their meeting.
He was apparently impressed with Guttman played the word "phat" in an early game, while the retiree was impressed with the "masterful alliteration" in Sleyon's username, "FUCKFACEFILTH", according to The Root. The tweet, along with the photos of the two hugging each other, has been liked one million times.
"She came to me weeks later and asked me how would I be interested in going to Florida for a day to meet her", Sleyon said.
Spencer said he had never been to Florida and thanked Ms Butler for making the meeting a possibility.