She was bleeped as she thanked her studio, Fox Searchlight, and then again when she said the word "shift".
The Oscar victor for Best Actress has also won a Golden Globe in 17 out of the past 20 years (with the asterisk that the Globes pick TWO Best Actress winners, one for drama and one for musical or comedy, every year).
McDormand - who was nominated in years past for such films as Fargo, Almost Famous, and Burn After Reading (and also received a special award in 1994 as part of the cast of Short Cuts) - plays a mother waging a war against local authorities when police fail to solve her daughter's murder. The film won the "Best Motion Picture" award in the drama category, and sent star Frances McDormand to the stage as victor of the "Best Actress" award in a drama. "It's 2018. Marijuana is finally allowed and sexual harassment finally isn't", quipped Globes host Seth Meyers in his opening remarks, bringing wild applause from the A-list audience in Beverly Hills. "Lady Bird" won the Best Motion Picture - Musical or Comedy, James Franco won Best Performance by an Actor in a Motion Picture - Musical or Comedy for "The Disaster Artist", Allison Janney won Best Performance by an Actress in a Supporting Role in any Motion Picture for "I, Tonya". The stars wore all black in solidarity of "Me Too" and "Times Up" in honor of sexual harassment and equality.
While it was a big night for streaming video companies, HBO - which has its own, popular subscription-based streaming service - also won big at the ceremony.
Women kept up the theme inside the Beverly Hilton ballroom.
"Folks, time's up", she said.
The Amazon series from the creators of Gilmore Girls, The Marvelous Mrs. Maisel also finished strong, taking home awards for best television series - musical or comedy, while awarding Rachel Brosnahan as best actress. News said he "made lemonade out of lemons".
In accepting the award for best drama series, "Handmaid" executive producer Bruce Miller punctuated his speech by saying, "To everybody working to stop "The Handmaid's Tale" from becoming real, keep doing that". "All you ladies in this category. tequila's on me".
"Speaking your truth is the most powerful tool we all have", Oprah said.
Sterling K. Brown was the only television network actor to take home a Globe, earning the prize for drama series actor for his work in NBC's "This is Us". "We see you. We hear you and we will tell your stories".