Crews arrived at 6.30 on Friday morning to a "significant fire" that was travelling across the main lines of the station, Bryn Coleman from Nottinghamshire Fire and Rescue Service told the BBC.
Flames were spotted by shocked eyewitnesses and smoke has filled the foyer area.
Sixty firefighters are tackling a "fully developed" blaze on the "main concourse" of Nottingham railway station, where flames have reportedly "spread to the roof".
Nottinghamshire Fire and Rescue Service Tweeted: "The cause of this fire has not yet been established - current focus is dealing with the incident and keeping everyone safe".
About 60 firefighters have been tackling a large fire at Nottingham station.
Trains will not be stopping at the station "until further notice" and East Midlands Trains expect disruption to services throughout Friday.
"We are aware of the incident and, at the minute, there are no reported casualties", she said.
Nottingham station has been cordoned off and no trains are being allowed into the station.
The incident has caused delays across the local transport network.
"The station has been evacuated and there have been no reports of any injuries to customers or staff".
"There is also extensive fire damage to the wooden bridge area which goes across Platforms 6 and 7".
No trains are expected to run again this morning as crews bring the fire under control.
"Please do not travel to Nottingham station this morning as trains will be unable to run and we are unable to provide road transport to/from the station".
Services from Newark Northgate Station to Lincoln have not been affected.
- Passengers should visit www.eastmidlandstrains.co.uk for the latest travel information.