A black Ford F-150 headed onto the emergency vehicle shoulder and hit the rear of the auto, also striking both people, state police said.
The driver of the pick-up truck, who identified himself as 37-year-old Alex Cabrera Gonsales of Indianapolis, fled the scene on foot. "Edwin was loved by all in the Colts organization", they wrote in a statement.
As of now, investigators believe Monroe stopped to attend to an ailing Jackson who was parked on the shoulder of the highway, via Justin L. Mack and Emma Kate Fittes of the IndyStar.
That season Jackson was the team's third-leading tackler, but he suffered a season-ending injury during the 2017 preseason so he spent the year rehabilitating. However he was released soon after and was signed to the Indianapolis Colts in December of the same year.
A spokesperson for Uber confirmed that Monroe was giving Jackson a ride early Sunday morning and said Uber was ready to help police with their investigation.
Jackson may have first pulled over, and the other man, who was later identified as Jeffrey Monroe, pulled over to see if Jackson needed assistance, police said.
Jackson played in the Cardinals' preseason games in 2015.
Police have arrested a man on suspicion of drink-driving. While slowing to stop for the crash, he struck the body of the victim in the center lane. Terrific young man, respected and liked by all.
In the 2016 National Football League season he played in all 16 games and started eight, recording 66 tackles. He was transported to the Marion County Jail and his toxicology results are pending.
"It is believed Gonsales was intoxicated and was driving without a license", Sgt. John Perrine of the Indiana State Police said in a statement. The Jackson family and the Colts have to be greatly saddened by this, and thoughts and prayers go out to everyone who is affected by this terrible event. "He earned everything that he was given and has left this world way too soon".
HollywoodLifers, share your condolences for Edwin's friends and family in the comments section below.
Former Colts punt Pat McAfee tweeted how much Jackson impacted the locker room and anyone that came into contact with him.