Van Dijk is set for his first experience of the rivalry since Liverpool secured his services in a £75million deal with Southampton in January, with two points separating Jose Mourinho's United in second and Jurgen Klopp's men in third.
The majority of the first-team were seen arriving for training today, including Zlatan Ibrahimovic and Ander Herrera as the injured duo edge closer to a return to action.
"It's going to be a very tough game going there, and they have so much quality - but we do as well".
"He doesn't concede many goals, or his teams don't concede many goals, and I think patience will be key because when you've got a lot of possession against United then I think the most unsafe thing is always to think we'll be fine, we won't concede, now let's commit one or two players more forward, and I think this is where they can hit you". "I feel that already, and have for the last few weeks".
Dejan Lovren is very proud of his team's undeniably attacking brand of football and he insists that Liverpool will go all out for the win against Manchester United this weekend.
"He doesn't strike me as a player who is bothered about what people say about him and if United create chances then he'll put them away".
"I'm definitely looking forward to it and I can't wait for it to start".
Lovren himself highlighted the confidence within the squad and said the Reds will look to attack on Saturday, rather than accepting a point. For them it will be maybe a point good but for us, we never play for a point.
"When you look, we still have nine league games to play and everything is open".
"You know you can never keep him out the game for 90 minutes Lukaku, because he is just too powerful and too quick and too strong for that".
Watch Lovren and van Dijk's interview above.