Stiers is best known for his role as the arrogant aristocrat and surgeon Major Charles Winchester on the iconic military sitcom.
Stiers had been battling bladder cancer.
Stiers played Winchester from 1977-1983 on the series, one of the most popular in TV history, twice receiving Emmy nominations for his work on the show.
The late actor was born in Peoria, Illinois, then moved to Eugene, Oregon while he was in high school. He briefly attended the University of OR and studied at the Juilliard School in NY in 1968.
Indeed, it was his voice that earned him his first screen credit - as the announcer in George Lucas' 1971 film "THX 1138". He followed that up with appearances in TV shows such as "Kojak" and "The Mary Tyler Moore Show".
M*A*S*H star David Ogden Stiers has died at 75
Stiers was also a gifted musician.
The next year, Stiers received another Emmy nomination - for portraying William Milligan Sloane, founder of the U.S. Olympic Committee, in the NBC miniseries "The First Olympics: Athens in 1896".
Stiers was also a gifted musician, the website reports, and was resident conductor of the Newport Symphony.
In addition to his live-action work, Stiers was a successful voice actor, most notably voicing Cogsworth in Disney's 1991 classic Beauty and the Beast.
He continued acting and doing voice-overs until 2015, with credits in video games, cartoons and television shows.