United will have been disappointed not to get closer to runaway leaders City this term, though one constant for them has been the form of De Gea, who is the only goalkeeper among the nominees.
However, there is also a surprise nomination with 17-year-old Fulham full-back Ryan Sessegnon the first player outside the top-flight to make the shortlist since the award's inception.
The six-man young players' list also contains three City players, with 22-year-old Germany global Sane nominated alongside England forward Raheem Sterling, 23, and Brazil goalkeeper Ederson Moraes, 24.
Egyptian superstar Salah has chalked up 29 goals in only 31 league matches for Jurgen Klopp's side in his first season back in England's top flight, and now leads the scoring charts - ahead of second-placed Kane - by four goals.
Sessegnon joins five Premier League men in the final six, including Harry Kane!
It has always been seen as a two-man race between Salah and De Bruyne for who will succeed N'Golo Kante as the PFA's Player of the Year.
To be eligible for the award, players must be 23 or under at the beginning of the season.
The inclusion of Sane and Silva alongside De Bruyne is an indication of just how dominant City have been in the Premier League this season.