They need just three points to be crowned champions, but they will win the title if Manchester United lose to West Brom on Sunday or to Bournemouth on Wednesday.
A United victory would keep City's celebrations on hold for a few more days at least.
Relegation-threatened Crystal Palace (+550) host Liverpool (-205, draw +340) in one of the Saturday betting matchups, with Liverpool no doubt preoccupied with a Champions League quarterfinal first-leg match against Manchester City on April 10.
An unlikely defeat by Manchester United at home to bottom club West Bromwich on Sunday would secure City's third title in seven seasons, but a win against Swansea next week will be enough to put them out of reach.
City's hellish week had Guardiola warning his players that "anything can happen" as he recalled other great sporting collapses from seemingly invincible positions.
"They had three defeats in a row".
If you happen to live outside the USA or United Kingdom, you can still stream the Manchester City v Tottenham online using a VPN.
Mohamed Salah has set his sights on breaking the Premier League record for most goals in a single season, Soccerway reports.
This structure presented an opportunity for Tottenham to exploit on quick turnovers as City's transition defense would be challenged with any wide attacks.
The foul was committed outside the box, so the decision to award a penalty was incorrect, but Lloris was ultimately fortunate not to be sent off by referee Moss for the foul.
The South Korea worldwide has now reverted to a wide role and is likely to line up directly against Walker, who left Tottenham a year ago, in the Premier League on Saturday.
Tottenham defender Ben Davies somehow escaped a red card for a disgusting studs-up foul on Kompany, but the leaders still had a soft centre to their defence.
Kane at least returned the favour as Eriksen scored in the 42nd minute.
Harry Kane fed him on the edge of the area and there was a large amount of fortune about the finish as his original effort rebounded off goalkeeper Ederson back onto the Dane and into the corner.
Luis Suarez gave Barca the lead after a quarter-hour by meeting a delicious outside-of-the-foot pass from former Liverpool teammate Philippe Coutinho, scoring with one touch from close range.
The move allowed City a foundation to bag the decisive third goal that all but sealed the title.
"We congratulate them, they are very close to winning the Premier League", the Argentine said after the match.
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