Manchester City would be crowned champions if the Red Devils is defeated in the game.
The result leaves City 16 points clear at the top with five games remaining and on a total of 87.
Yet they still clinch the trophy with five games to spare - a joint-Premier League record - after dominating the division for most of the campaign. "All the few players [who were injured] are ready to play".
Midfield: Paul Pogba inspired United's stunning comeback against City last week and the French worldwide is expected to keep his place in midfield following his two-goal display.
"Everyone is ideal, apart from Romero", said Mourinho in his press conference ahead of the game.
David De Gea has been enormous for the 20-time English champions once again this season.
Not for the first time this season at Old Trafford United started sluggishly and could have been a goal down after 12 minutes.
In defence, Phil Jones and Daley Blind are back from injury after spending a significant amount of time out on the sidelines.
Antonio Valencia should once again start at right-back but Mourinho may decide to give Ashley Young a rest so Marcos Rojo could start at left-back as he seems to be ahead of Luke Shaw in the pecking order.
Lukaku has gone from strength to strength following his stint at West Brom, enjoying a goal-laden spell with Everton before joining Man United last summer.
Mata sliced wide from just outside the penalty area before the ineffective Pogba was hauled off for Anthony Martial just before the hour in a desperate attempt to inject some spark into United's lifeless attack.
The Ivorian is one of two changes Mourinho has made from the starting XI that went on to win a thrilling Manchester derby last weekend against City. The Belgian scored in the return fixture against the Baggies in December previous year and will be hoping to do more damage against his former side at Old Trafford on Sunday.