France manager Didier Deschamps has named his 23-man squad for the Russian Federation 2018 World Cup with some big names placed on standby.
Dimitri Payet, who was injured as Marseille lost Wednesday's Europa League final to Atletico Madrid, is also a notable omission as is Bayern Munich forward Kingsley Coman.
"He was a serious candidate for a place in the 23 but for this kind of injury it's usually three weeks of recovery", Deschamps told reporters.
"I consider Giroud, (Antoine) Griezmann, (Nabil) Fékir and (Kylian) Mbappé as central attackers".
Kante, recently named Chelsea's Player of the Year, will head to Russian Federation hoping to help his nation lift the World Cup two decades on from their maiden and to date only triumph in the competition. The biggest surprise came with the inclusion of Sevilla's holding midfielder Steven Nzonzi, who was preferred to Paris Saint-Germain's Adrien Rabiot.
France are without defender Laurent Koscielny, who suffered a major Achilles injury in Arsenal's Europa League semi-final against Atletico. Samuel Umtiti, Raphael Varane and Adil Rami will be in contention for the center-half position.
France have been drawn in Group C this summer and begin their World Cup campaign against Australia on June 16.
Prior to their departure for Russia, France will take on Ireland, Italy and the United States in friendlies.
However, Manchester United forward Anthony Martial, Arsenal striker Alexadre Lacazette and Paris Saint-Germain midfielder Adrien Rabiot are all placed on standby along with eight other players.