Exact Sciences stock jumped as much as 13 percent on Wednesday after the American Cancer Society said people should be screened for colorectal cancer at age 45, lowering its guidelines from the current recommended age of 50.
"Fight Colorectal Cancer commends the American Cancer Society's leadership announcing a significant change in the colorectal cancer screening guidelines for average-risk patients from 50 years of age to 45".
Colorectal cancer is the fourth-most commonly diagnosed cancer among adults and the second-leading cause of cancer death, in the United States.
When the cancer society started to update its recommendations, it initially focused on racial groups that have higher death rates from the disease, primarily African Americans. Rather, to maximize the chances that people will take up screening, the cancer society wants physicians to offer patients a choice of six different screening options, from the most invasive procedure, colonoscopy, which can be done every 10 years, to lab tests done on stool samples that can be collected at home, which must be repeated more often and followed by colonoscopy if results are positive.
For colorectal cancer, the American Cancer Society didn't push one screening option over another but listed various options: High-sensitivity stool tests, created to detect blood in feces, which need to be administered every year; a DNA stool test, sold under the brand name Cologuard, every three years; a colonoscopy, every 10 years; or a virtual colonoscopy or flexible sigmoidoscopy, every five years.
"Be aware screening is important, screening can save their lives, screening can actually prevent colorectal cancer", said Church.
Doctors aren't sure why colorectal cancers are increasing in younger adults.
The American Cancer Society says it endorsed the full range of screening tests "without preference" in order to improve the rate of screening.
Because it is almost impossible to ask large cohorts of people to start colorectal cancer screening at different ages and then follow the outcomes of these cohorts, determining the best age to start and stop screening, and the optimal frequency of screening, depends on sophisticated mathematical models. It used existing data to estimate the effects of screening at age 45.
"We see higher incidents in communities that have obesity".
Consuming red meat, processed meat and alcoholic beverages, among other factors, could increase the risk of colorectal cancer."There is excellent evidence that we are doing the right thing". Meanwhile, clinicians should discourage individuals over age 85 from continuing colorectal cancer screening, according to the ACS.
Dr. Nilofer Saba Azad, associate professor of oncology at Johns Hopkins Medicine in Baltimore, agrees with the newly updated guidelines. With that, we've noted that the incidence is going up in younger people, even younger than 45.
Since adults in their 40s are far less likely to be screened than those in their 50s, the true underlying risk in adults between 45 and 49 likely is closer to the risk in adults between 50 and 54 than the most recent age-specific rates would suggest, studies say.