The Pirates Of The Caribbean actor is now on tour with his band, The Hollywood Vampires, however pictures taken of the 54-year-old looking gaunt during their recent stop in Hamburg left many fans anxious.
But Depp shot "Richard Says Goodbye" in the summer of 2017, so any dramatic weight loss for the role would have taken place a year ago.
The shocking snaps posted on social media show the 54-year-old looking thin and sickly as he poses with two make-up artists at the Four Seasons Hotel Lion Palace in St. Petersburg in Russian Federation. Johnny has not publicly commented about the photo. The actor has a massive fan following who are insane about him and that is the reason why they are anxious seeing his latest pictures. Could it just be a bad camera angle, or the fact that he had ditched his signature black "guy liner?"
"I think my hero looks ill", one user commented on Facebook of the shared fan photo.
Depp was also defended recently by director Brad Furman after allegations emerged that the actor had caused a "toxic" environment on the set of new film City Of Lies, and asked a crew member to punch him.
But fans who attended his shows cast doubt that there's a problem. He looks healthy, happy and he had so much fun.
The supergroup features a host of famous musicians, including Joe Perry from Aerosmith and Alice Cooper. "My life is complete", she wrote.
In January, Depp filed a lawsuit against his former business managers at the Management Group, alleging claims including fraud and negligence.
Then again, if Depp is looking a little a bit haggard, it could be because he's weathered a rough few years, personally and professionally.
Another added: "Johnny Depp's latest picture has left everyone in shock".
While Depp's attorney said Amber's claim was "to secure a premature financial resolution" in the divorce, she ended up donating the money won to multiple charities.