The Premier League clubs will meet at the Aviva Stadium on Wednesday, August 1.
The match will also be new Arsenal manager Unai Emery's first in English football's top flight.
The first Manchester derby, which will pit last season's top two against each other, is due to take place on November 10 when Jose Mourinho's United make the short jounrey across town.
It is a similar story for neighbours United, who begin at home to Leicester.
They will play promoted Fulham at Wembley in their first home game of the season on the weekend of 18-19 August.
Our final pre-season fixture takes place just two days after the Community Shield, so you can expect a heavily rotated side.
And there is expected to be more additions in the coming weeks as the Liverpool boss looks to build a squad capable of battling for the title next season.
Antonio Conte's Blues travel to Huddersfield on the opening day and after the trip to Arsenal come Newcastle, Bournemouth, Cardiff, West Ham, Liverpool and Southampton.
Jurgen Klopp's side enjoyed an up-and-down season a year ago as their free-flowing attacking football drove fear into every Premier League defender.
But given the way that the club handled the expectations and pressure of this past season and have wasted little time getting deals done this summer, it may not be a huge surprise if those closer to the periphery of the top six were concerned about what the newly-promoted side may achieve.