Neuer made the squad despite playing in just one official game, a friendly against Austria on Friday, since breaking a bone in his foot in September but talented 22-year-old Sane was the biggest name to miss out.
Germany have included 2014 World Cup-winning goalkeeper Manuel Neuer in their final squad for the 2018 tournament, even though he has only just returned from a long-term absence through injury.
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The PFA Young Player of the Year, who found the net 10 times and contributed 15 assists in City's rampant Premier League campaign, is the surprise absentee on the list, with young Julian Brandt preferred.
And having missed out on last summer's Confederations Cup triumph due to nasal surgery, Sane won't head to Russian Federation this summer either.
Considering he's a regular starting player in Pep Guardiola's glittering side, Sane could be forgiven for wondering why he lost out to Julian Brandt, Marco Reus and Julian Draxler. Draxler, Reus and Muller are set.
"That was a very close decision between him and Julian Brandt, which was made in favor of Brandt". Leroy has a huge talent. "He will be back again from Sept", Low said. "If it was a 100 metre race, it would have been a photo finish".