The major issue is at left-back, where Sead Kolasinac is definitely out and Nacho Monreal is considered doubtful, which may mean Ainsley Maitland-Niles starting. City's left-back missed nearly the entirety of last season through injury, and his overlapping will bring an extra dimension to City's attacking play.
It's a new dawn at Arsenal!
The match can be viewed on Sky Sports Premier League in the UK.
In defence, Guardiola would go with John Stones and either of Nicolas Otamendi or Aymeric Laporte.
Unai Emery has declared his desire to keep Welsh midfielder Aaron Ramsey at Arsenal, but insists he will not be the one to handle the contract negotiations.
Despite last season's stunning achievements, Guardiola was his usual guarded self when talking about City's prospects for the year ahead, believing as many as five other teams could prevent him from becoming the first manager in a decade to retain the title.
Arsenal kick off their 2018/19 campaign when they welcome defending champions Manchester City to the Emirates this afternoon.
Just moments later the points were secured as Benjamin Mendy's cut-back was turned home brilliantly by Bernardo, with substitute Kevin De Bruyne's last-gasp strike tipped over the crossbar.
The opening weekend of the new Premier League season has served up a delicious treat.
Pep Guardiola snapped up Riyad Mahrez from Leicester City in the summer and he will start out wide.
So it proved. For all the undeniable optimism around the Emirates before kickoff, the first 45 minutes demonstrated that Arsenal have plenty of room for improvement under new boss Emery. Emery has faced a Guardiola side 10 times and never won.
Manchester City played with the same level of control and authority as last season, dominating possession throughout the game, pressing well and involving their forwards regularly. But, he has failed to make a good first-impression, largely thanks to his wobbly form in the pre-season.
Arsenal's defensive signings will give their forward players more freedom and Aubameyang is one to exploit this and torment the opposition.