The news that Grande won't be performing during the SNL premiere comes on the heals of a tough month for the singer and a series of tweets that suggest she is having a hard time as she grieves for her ex-boyfriend and longtime friend, Mac Miller, who died of an apparent overdose earlier this month.
"I'm trying to get my work done and get back to normal and it's hard and I'm human and exhausted", Grande said.
Her news comes after the singer anxious fans with a series of messages on her social media just last week.
Michaels then told Miller, who wrote the SNL oral history Live From New York: An Uncensored History of Saturday Night Live, that the Ariana Grande/Kanye debacle proves that the show is still at the height of its popularity.
Miller, who she broke up with in May, had long suffered from addiction and died of a suspected drug overdose September 7.
Ariana and fiance Pete Davidson skipped their scheduled appearance at the Emmy Awards, and her rep said she would be taking time to be at home with loved ones.
Fans began reaching out to Grande following the emotional tweets, prompting her to respond, "ty for loving me sm I do not deserve it".
Ariana is now engaged to SNL comedian Pete Davidson, 24.
She added: "I'm so sorry I couldn't fix or take your pain away".
Grande's words to her fans follow her tweets from Thursday where she wrote that she was "so f-king tired" and needed a break. I really can't wrap my head around it...
The 25-year-old was, of course, referring to the Manchester bombings in 2017, which tragically claimed the lives of 22 people.