Ghana is the jumping-off point for her first major solo global trip for Melania as first lady, a tour of Africa, a continent her husband reportedly referred to derisively.
Melania has been criticised for everything from her outfit choices to reading to African children and even visiting elephants.
It was the second time in as many days that the first lady promoted policies out of step with her husband's.
Mrs Trump opened her first extended solo worldwide trip on Tuesday in Ghana. The Secret Service whittled down the list of available options for security reasons, and then Melania picked countries where she could mix work with a small amount of tourism.
Trump also had tea with Ghana's first lady, Rebecca Akufo-Addo, at the presidential palace.
Mrs Trump has also said she is looking forward to meeting her Kenyan counterpart.
She will visit Malawi, Kenya and Egypt as well. "Takulandirani [Welcome] First Lady Melania Trump" was spelled out in red, white, and blue letters on the chalkboard. It is a attractive thing to see.
She took photos on her iPhone of zebras, giraffes, impalas, rhinos and hippos.
But none of that was up for discussion as Mrs. Trump visited with happy schoolchildren and their teachers in the Malawian capital. She'll also go on a quick safari. The first lady thanked educators for helping the children "be best" throughout their school experience.
Their talks focused on matters of health especially the welfare of mothers and children, and conservation, State House said.
"When people think of Africa, they have these standard narratives", Kim Yi Dionne, a political science professor who specializes in African politics at the University of California, Riverside, told the Times.