Israeli prosecutors say Sarah Netanyahu is accused of misuse of funds, paying almost 100,000 USA dollars for food deliveries.
The Netanyahus have denied any wrongdoing, and say they are the victims of a political witch hunt driven by a hostile media.
Sara Netanyahu, wife of Israeli Prime Minister Benjamin Netanyahu, leaves the Magistrate's Court in Jerusalem al-Quds on October 7, 2018.
The Israeli Prime Minister on Sunday announced he had agreed to meet Russia's President in a bid to reduce tension between both countries over the situation in Syria.
Netanyahu is suspected of bribery, fraud and breach of trust in "Case 1000", also known as the "Gifts Case", regarding his relationship with Israeli businessman Arnon Milchan and Australian businessman James Packer.
"For the first time in history, charges are being pressed against a leader's wife over noodles and take-away containers from six to seven years ago", a statement from her lawyers said Sunday.
The police claim that the two have given Netanyahu for many years various types of benefits in return for receiving certain perks.
The Netanyahus are fighting multiple charges of corruption and this is the first to go to trial.
Police have recommended Benjamin Netanyahu be indicted in two cases, though the attorney general has yet to decide whether to do so.
Elovitch was arrested in February along with six other people, including Nir Hefetz, a former media adviser to the Netanyahu family who has turned state witness. Another ongoing inquiry involves the prime minister offering a different mogul to push forward government policies favourable to his telecom business in exchange for positive coverage in his news site. The move has been denounced not only by the Jewish state but also by the United States and France. If Mr Netanyahu were to step down, polls show one possible replacement would be hard-right Education Minister Naftali Bennett, who has proposed annexing much of the occupied West Bank and openly opposes Palestinian statehood.
Wife Netanyahu rejects the accusations and calls them "baseless".