The two were teammates for Lara, which played at Caracas on Thursday night.
The New York Times says all three players were Venezuela natives. He joined the Angels prior to the 2017 campaign, ultimatly being released by Los Angeles in August.
The Cubs claimed the left-handed hitting Valbuena from the Blue Jays at the start of the 2012 season.
According to reports, both Castillo and Major League Baseball free agent Luis Valbuena were killed when their auto hit a rock in the road, and crashed.
Valbuena played 11 seasons in the majors, beginning his career in 2008 with the Seattle Mariners. Castillo, 37, played in the majors as an infielder from 2004 to 2008 with the Pirates, Giants, and Astros. He recorded a.254 batting average, 39 homes runs and 218 career RBIs.
He played mostly second base and third base. Carlos Rivero, who briefly played for the Arizona Diamondbacks in 2014, was driving the auto and survived the incident. He had four hits in seven at-bats with a walk during the late-August/early September appearances.