The crash occurred about 2:40 a.m. and Arkansas State Police said some of the injured were found trapped inside the bus.
State police said the bus overturned after driving off the interstate. The hospital said it has set up a family center so parents can reunite with their children. Those injured were a mix of children and adults, and they were taken to various hospitals in the area. Police said most of the injured were children who were taken to hospitals in Little Rock and Benton.
State police said the driver told investigators he lost control of the bus but it was not immediately clear what caused him to lose control.
Tragedy struck an Arkansas highway Monday when a youth football team from Memphis was involved in a bus crash as it traveled back home from a tournament in Texas. It gave no age for Kameron, but it said he was a third-grader at Aspire Coleman Elementary School in Memphis.
A bus crash in April killed 10 players on the Humboldt Broncos junior hockey team in Canada while the team was on its way from Humboldt to Nipawin in Saskatchewan. The bus was hoisted upright and pulled from the scene late Monday morning.
Two patients underwent emergency operations, said Chanda Chacon, the hospital's chief operating officer.
"When troopers arrived at the scene, numerous children were already off of the bus", Sadler told CNN. They were treated for bruising, lacerations and some orthopedic injuries then released. The hospital said all the patients were in stable condition, though no additional information about the injuries has been released. A spokeswoman said she couldn't provide any details, citing privacy laws.
The community was created after the Civil War by and for African-Americans, and black-owned businesses flourished there until desegregation enabled residents to live elsewhere.