The former first overall draft pick by the Clippers in 2009 was surprisingly traded to Detroit last January after signing a five-year extension worth $171 million.
Before the afternoon matchup at STAPLES Center, Clippers owner Steve Ballmer was waiting on the sideline as Griffin and the Pistons warmed up, according to multiple reports.
"As soon as I'm done doing my pregame shooting, I make sure there's a path and I take off running to the locker room and I don't stop running", Griffin told reporters.
Griffin was greeted with a standing ovation and tribute video in his return to L.A.
When asked if he would shake hands with Ballmer if he was approached at another time, Griffin answered, "I'm honestly not here to answer hypothetical questions".
Detroit centre Andre Drummond added 20 points and 21 rebounds, including nine on the offensive end.
"We're really happy to get the win for Blake", Bullock said.
You can't blame Griffin if he did not want to reminisce with Ballmer about his time in Los Angeles, which ended on a bad note. Bradley finished with three points.