By the end of the game Klopp had 18-year-old Comacho at right-back, Hoever in the middle alongside Fabinho - who was playing out of position - and Alberto Moreno at left-back while 17-year-old Jones was stationed on the wing. They lead the league by four points after 21 games and are through to the round of 16 in the UEFA Champions League.
Premier League leaders Liverpool played a weakened team in the third-round match against Wolves, and struggled to get going against the midlands club, losing 2-1 to go out of the competition at the first hurdle.
It's disappointing that the Reds are out of another cup competition, but Klopp is entitled to use the full depth of his squad and players such as Moreno and Simon Mignolet deserve to have a chance to play.
Youngsters Rafael Camacho, Curtis Jones and Ki-Jana Hoever all made their senior debuts in the defeat at Wolves.
"The goals we conceded against Wolves were really poor".
"Two or three of that line up won't be at the club come the start of pre-season".
"James Milner has been nearly faultless this season but he made a bad mistake and got punished with their opening goal".
"I don't want to name names but we all know who they are".
"It was a great hit but he shouldn't have been allowed to get the shot away". Monday night underlined that they need to be replaced. I saw the ball inside already, but it never went in.
Shearer also said that Klopp's decision to rest a number of players was a gamble, adding: "He's looking to these guys to give him a performance - they failed miserably".
"You certainly couldn't attach any blame to the young lads".
The African defender underwent surgery on the problem and is close to a return to first-team training ahead of their next Premier League fixture against Brighton on Saturday.