She went on to thank those who helped her with her album.
Though it's her name on the album, Grande didn't do it alone, and she acknowledged this.
While Cardi B, Travis Scott, Pusha T and Nipsey Hussle all had incredible albums past year, people thought the late Mac Miller might take home the gong for his fifth studio album Swimming, which was also nominated for the category.
The "God is a Woman" singer posted a series of now deleted tweets following the announcement, showing just how pissed off she was that her former lover wasn't honoured at the ceremony.
"There's a version where I was getting married, there's a version where I'm not getting married, there's a version with nothing - we're not talking about anything", she continued.
At first, some thought she was referring to Cardi's win, but Grande later clarified that it had "nothing to do w her".
She has since covered up the number with a tribute to her late boyfriend Mac Miller and his dog Myron.
This is the singer's first ever Grammy Award win.
That's not all! Ariana also reacted to the win and said, "i know i'm not there tonight (trust, i tried and still truly wished it had worked out tbh) and i know i said i try not to put too much weight into these things. but f**k. this is wild and attractive. thank you so much". One particular award touched a nerve with Grande: Cardi B being awarded Best Rap Album.
Sadly for the rapper, who died past year, Cardi B beat him for her album Invasion of Privacy.
She thanked him in her acceptance speech, as well as their seven-month-old daughter, Kulture. I basically worked with her to mold it.
The Bronx rapper's debut studio album Invasion of Privacy beat Pusha-T (DAYTONA), Nipsey Hussle (Victory Lap), Travis Scott (ASTROWORLD), and the late Mac Miller (Swimming), who had dated Grande for almost two years.
It has ben a whirlwind year for the rapper who released her debut album in April last year.