And Clooney, 57, leaped to defend his friend, saying history was repeating itself in the case of the Duchess and Diana, warning "we've seen how that ends".
George Clooney has come to the defence of Meghan Markle in a new interview. (AAP) Meghan has faced eghan has also faced intense interest from the United Kingdom press since her relationship with Prince Harry was revealed.
Clooney is a friend of Meghan's and he and his wife, Amal Clooney, attended Meghan and Prince Harry's wedding a year ago. More recently, another popular Princess of Wales was widely regarded to have been hounded to her death in a auto crash in 1997 by intrusions into her private life.
If you missed the speech, you can check out the Kensington Palace video below and it really is rather lovely.
The Hollywood star is a close friend of Harry and Meghan and he and his human rights lawyer wife Amal attended the royal wedding in May previous year as well as reportedly visiting the couple at their Cotswolds home.
Harry and Meghan watched a special performance of The Wider Earth, a critically acclaimed theatrical production about the young Charles Darwin's expedition on HMS Beagle.
His intervention comes amid reports of a rift between Meghan, who is pregnant, and her father, Thomas Markle. She wrote: "You fixated and clicked on the lies they were writing about me, especially those manufactured by your other daughter, who I barely know. It's irresponsible. I'm sort of surprised by that".
In a 2017 BBC documentary, William described paparazzi who followed her as "a pack of dogs" that "followed her, chased her, harassed her, called her names, spat at her, trying to get a reaction, to get that photograph of her lashing out".
The letter received widespread coverage in Britain, with The Mirror newspaper consulting a handwriting expert to claim that the Duchess's writing reveals her to be "emotionally insecure and self-pitying".
Previous sensationalist headlines in British tabloids since Meghan's marriage to Harry have focused on her alleged "tantrums" and her "tit-for-tat war" with Catherine.