George drew "MVP" chants from the crowd as he sealed his third career triple-double, the last coming back in 2014.
Westbrook, who finished with 21 points, 14 rebounds and 11 assists, reached the milestone after assisting Paul George with a three-pointer. Westbrook passed Wilt Chamberlain for the record with Monday's performance.
Oklahoma City Thunder forward Jerami Grant (9) and guard Terrance Ferguson (23) and guard Russell Westbrook (0) celebrate after a play during the fourth quarter against the Houston Rockets at Toyota Center.
It was just the latest performance in what is becoming a monster season for the 28-year-old.
George poured in a magnificent 47 points, laid on 10 assists and took 12 rebounds.
As a result, George was named to his fourth straight All-Star Game and is considered one of the top candidates for the MVP award in what has been, easily, the best season of his nine-year National Basketball Association career.
"This is the best I've felt mentally", George added.
"I know what I'm capable of doing, and I just go out and compete and whatever happens, happens, man", he was quoted as saying by ESPN. I go out and compete every night and leave it on the floor.
The figures make George and Westbrook the first teammates in National Basketball Association history to record triple-doubles in the same game with both players scoring at least 20 points in the process. "I'm very, very blessed to be able to go out and play, and I don't take it for granted". "I didn't know it was that close". "But [Westbrook] told the situation, so it was cool to be on the other end of the triple-double".
And it was George who sank a three-pointer with 3:52 left on the clock in the fourth quarter, which gave Westbrook his 10th assist of the night. Oscar Robertson is the only other player in league history to have averaged a triple-double throughout a season.
"It's incredible to go out and compete", he said, "to see your teammate, your brother, do unbelievable things, and you can be right on the side of him doing something special as well".