The night belonged to Messi, though, and the 31-year-old completed yet another memorable hat-trick with a pinpoint lob late on.
All that separated the two teams in the opening 45 minutes were moments of individual magic, and Messi provided the first of those with a stunning free kick after 18 minutes, leaving Pau Lopez no chance despite shooting at the goalkeeper's side.
What did you make of Messi's display on Sunday?
Betis is welcoming Barcelona in round 28 of Spanish LaLiga.
Suarez shot tamely at Lopez when presented with a great chance by Messi but the duo combined for the Barca captain's second goal on the stroke of half-time.
Messi Leads Barcelona with 26 goals and 12 assists in 25 games while Suarez added 17 goals. In LaLiga, Barcelona is on the top with 19 wins, 6 draws and only 2 losses and 69 scored goals and only 26 conceded goals.
The Barcelona star curled in a free-kick, finding the top corner with a devilish left-footed strike.
The Argentine chipped Pau Lopez from an nearly impossible angle and the rival fans applauded Messi for the genius that sparked the goal.
Messi was not done there, though, and he came within inches of a fourth goal with the final action of the match when he poked the ball against the inside of the post and watched it bounce across the line and out.