Health recommendations are ultimately based on the most current knowledge available, which means that new, long-term study results might overturn recommendations we once accepted as fact - like how eating lots of eggs was bad, then fine, then bad again.
"This makes the biggest difference", he said, "probably negating any previously perceived aspirin benefit in primary prevention".
European guidelines recommend against the use of anti-clotting therapies such as aspirin at any age.
Dr. Roger Blumenthal, a cardiologist with Johns Hopkins Medicine in America, says clinicians should be selective in prescribing aspirin for people without known cardiovascular disease.
However, aspirin was also associated with a 0.47 percent higher absolute risk of severe internal bleeding.
"It's much more important to optimize lifestyle habits and control blood pressure and cholesterol as opposed to recommending aspirin", said Blumenthal. But the research found that people taking low-dose aspirin were just as likely to die over the course of the study period than those taking a placebo. It estimated that if 10,000 people took low-dose aspirin every day for a year, four fewer would suffer a heart attack or stroke than if none of the 10,000 had taken aspirin, while seven more would suffer serious bleeding in their skull, brain, stomach or gut. In addition, the study did not evaluate the effect of daily low-dose aspirin on people younger than 65.
And according to doctor Deidre Mattina, a Henry Ford Hospital cardiologist.
Other recommendations in the report aimed at minimizing the risk of cardiovascular disease include engaging in regular physical activity, avoiding tobacco and focusing diets on "vegetables, fruits, nuts, whole grains, lean vegetable or animal protein, and fish". If additional medications are needed, two new classes of medications are showing promise in reducing cardiovascular events in those with Type 2 diabetes: SGLT-2 inhibitors, which work to increase glucose and sodium removal via the kidneys; and GLP-1R agonists, which increase insulin and glucose production in the liver.