There was no reference to an injury for Cokanasiga but Jones will explain his decision in a news conference later on Thursday.
In total there are four changes in personnel to the XV that battered Italy 57-14 at Twickenham with Ben Moon restored at loosehead prop and Mark Wilson displacing Brad Shields at blindside flanker.
Joe Cokanasiga is bound for the World Cup after Eddie Jones claimed the giant wing is capable of becoming a Test centurion despite his shock exclusion from England's clash with Scotland.
"We have had a good preparation and the side is going to be in a great state to play against Scotland on Saturday". We'll bring him through carefully and he's got a long career ahead of him.
Jack Nowell grabbed the first try after 56 seconds and further scores by Tom Curry, Joe Launchbury and Jonny May - his sixth of the championship, had them 31-7 up at the break after Stuart McInally scored a charge-down try in a rare bright moment for the visitors.
Ben Youngs will become England's most-capped halfback in making his 85th appearance, one more than Danny Care on the all-time list.
"It is a fantastic achievement for Ben, it takes a lot of dedication and hard work and something he and his family will be really proud of", Jones said.
Jones said there was nothing planned in terms of watching the earlier game. "'You've got to keep players" feet on the ground, ' he said. "If Wales win, so be it".
The Six Nations title might be out of reach for England at kickoff in the closing match of the tournament against Scotland at Twickenham.
There isn't a single member of Gregor Townsend's playing squad who was born to see Scotland beat England away 26 years ago, 22-12. "It's another game. We're defending the Calcutta Cup, which is massive for us".
"Sometimes you let them go and sometimes you pull them back a bit". "I think we are clearly getting really good clarity about the way we want to play and the way we can be the best in the world".