At 0:58 seconds of the fourth round, Lomachenko scored the knockout victory to successfully, easily and very violently retain his unified WBO/WBA lightweight titles.
Campbell could be a potential opponent for Lomachenko as he has earned a mandatory shot at the WBC title now held by Mikey Garcia, who is yet to announce if he will vacate the belt.
Crolla, meanwhile, had said in advance of the fight that he was prepared to "shock the world" when he was plugged into the bout as an injury replacement for IBF champion Richard Commey, but in truth it was a poor performance from the the Englishman.
Lomachenko outlanded Crolla 72-12, according to CompuBox, and limited his opponent to five punches landed or fewer in all four rounds.
Although Crolla retreated and dodged Lomachenko's attacks from the opening minute onward, Lomachenko picked apart Crolla's defense with his peerless combination of athleticism and technique, working the body and head with equal aplomb. Crolla lost the title to Jorge Linares back in 2016 and lost the rematch as well. Losing to Lomachenko is never a disgrace. The Ukrainian has developed a significant fan base in the boxing-savvy Los Angeles area, where he lives and trains.
His profile has grown after headlining at Madison Square Garden and other LA venues before stepping up to Staples. 'I feel like I'm in Ukraine here'.
Had Lomachenko not taken the Crolla fight, he would have been stripped of one of his belts.
In the co-main event, longtime super middleweight champion Gilberto "Zurdo" Ramírez remained unbeaten when his light heavyweight debut against Tommy Karpency was stopped by Karpency's corner before the fifth round.
The knockout punch was so loud it could be heard by those sitting outside the ring.