At least one adult has also been hospitalized.
Five young children - including four siblings - were killed in an early-morning blaze at an Erie, Pa., day-care center Sunday, according to emergency officials and local news reports.
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The fire bureau's two fire inspectors and three Erie Bureau of Police detectives who are trained in fire investigators are working to determine the cause of Sunday morning's fire, which caused heavy damage to the front of the three-story house.
Five children were pulled from the house died, while a sixth person was flown to UPMC Mercy in Pittsburgh for treatment, a spokesperson for the Erie Police Department confirms to PEOPLE.
"So we are all at a loss, trying to figure out how this happened", Lockett-Slupski told the newspaper.
The grandmother of four of the victims, Valerie Lockett-Slupski, said her grandchildren, two boys and two girls, died. He said a neighbor was also injured. The Erie Times-News reported that a woman sent to hospital with injuries from the fire is the owner of the daycare.
Chief Fire Inspector John Widomski told the outlet that flames were bursting out of every window of the house's first floor when firefighters arrived.