An analysis also revealed a potential association between the combined blood test plus CT lung screening method and decreases in all-cause and lung cancer mortality, though the study was not created to detect statistically significant differences in mortality rates for the first two years.
The blood test uses Oncimmune patented technology to detect the presence of auto-antibodies generated by the body's immune system as a natural defence against cancer cells.
The view of doctors discussing the data on twitter at the lung cancer conference was broadly supportive, and further figures from AMG 510 will be announced at the European Society for Medical Oncology (ESMO) 2019 Congress at the end of the month.
This study moves us closer to making an earlier diagnosis of lung cancer, which could have a significant impact in saving lives. Of the cancers detected in the intervention group, significantly more of them were detected at an earlier stage when they were more likely to be curable. This can include a persistent cough, coughing up blood, weight loss or chest pain.
"If I hadn't had that blood test I would never have known".
The second group were given a blood test at the outset, and those with a positive result were offered immediate X-ray and CT scans, with follow-up scans every six months.
Among those people who received the EarlyCDT Lung test and went on to develop lung cancer within the next two years, 41.1% were diagnosed at an early stage (stage 1&2) of the disease, compared with 26.8% among the control group subject to standard clinical practice. This is due primarily to late stage of presentation.
The EarlyCDT Lung test is a novel autoantibody diagnostic test for the early detection of lung cancer allowing stratification of individuals according to their risk of developing lung cancer.
Lifelong smoker Rebecca Allison, 69, from Glasgow, was among those who had a positive blood test. It can detect all types of lung cancer at all stages from stage I to stage IV.
Pastorino had previously reported that that microRNA expression profiles in tumors and, for the first time, also in normal lung tissue, are indicative of aggressive lung cancer development and that specific microRNA signatures can be identified in plasma samples of patients up to two years before spiral-CT detection of the disease.
Oncimmune Holdings said it had presented positive study data at an industry conference in Barcelona.
Mr Sullivan said: "These landmark findings are likely to have globally significant implications for the early detection of lung cancer by showing how a simple blood test, followed by CT scans, is able to increase the number of patients diagnosed at an earlier stage of the disease, when surgery is still possible and prospects for survival much higher".
"BioMild showed that the combination of microRNA assay and LDCT is a valuable and safe tool to assess individual risk profile and reduce unnecessary LDCT repeats in lung cancer screening", said Dr. Pastorino. Stable disease and responses were also observed among patients receiving the drug at the 180mg, 360mg and 720mg doses. Scotland also has one of the poorest survival rates from lung cancer in Europe - only Bulgaria and Wales are worse.
Scotland has had one of the highest rates of lung cancer in the world. More recently the UK Lung Cancer Screening Trial and the NELSON trial reported successful early detection of lung cancer using low dose CT scans.
The ECLS study was co-funded by the Scottish Chief Scientist Office, Scottish Government and Oncimmune.