Crucially, they lost to City at the Etihad in April, after Riyad Mahrez scored the only goal in a 1-0 win.
However, both are obviously expected to return to the lineup for the Manchester City game to combine with Mohamed Salah in the Liverpool frontline.
The Premier League's rule changes reflecting the International Football Association Board's "Laws of the Game" this summer called for a foul when a player has made their body "unnaturally bigger", but the referee appeared to determine that Alexander-Arnold's outstretched arm was natural.
If they are to inflict Liverpool's first defeat in 29 league games, particularly with Claudio Bravo in for Ederson and question marks lingering over David Silva and Rodri, they will need to put their best foot forward.
"Right now Liverpool are the strongest team in the world". Anything other than a win and it is still game-on for both teams.
Some have suggested the match is a must-win for City, it's worth remembering they were seven points behind Liverpool in January and went on to win the title.
However, Klopp's record stands firm against Guardiola.
"Man City is a pretty good football team".
Liverpool, though, are a magnificent side driven by a self-belief that not only fuels Klopp's team but has sown the seeds of doubt and fear in opponents, as shown at Villa Park last Saturday when a 1-0 deficit after 86 minutes became a 2-1 win by the final whistle.
A win for City would pull them within three points of Jurgen Klopp and company.
"Do City and Liverpool play tactics here?" City can't afford to lose and Liverpool may be frightened of losing so it could be a bit more cagey than some are expecting.
"A draw would see Liverpool maintain their six-point lead over City while Pep Guardiola's side would surely settle for a point with Aymeric Laporte out with a long-term injury".
"City will field two of Nicolas Otamendi, John Stones and Fernandinho in the centre of their defence and it will be hard for the visitors to keep Liverpool's front three and especially the hugely influential Sadio Mane at arm's length".
"If you just think "Let's see what happens" against that team there I think it's not possible".