The England captain is contending with an upset stomach just four days out from the Port Elizabeth contest.
The series is now locked at 1-1 with the next Test starting from January 16, which overlaps with the final day of the next round in their domestic four-day competition, making it very likely that the hosts will go in with the same team barring injury.
It ended up being a blow for England whenever Rory Burns, which made 84 into the second innings of this first Test, ended up being injured prior to the 2nd match but Dom Sibley stepped up with an essential century whilst Joe Denly was solid at number 3 without taking place to a huge rating.
South Africa were then dismissed for 134 the second time around, with legendary English quickie Frank "Typhoon" Tyson claiming 6/40.
Bowling conundrums: Notwithstanding Rabada's feats in 2017/18, spin bowlers generally expect some help from the St George's Park pitch.
England will be riding on a wave of confidence after Newlands, but hopes that first choice slow bowler Jack Leach would be rejoining the party have been dashed.
Five of those losses were in Sri Lanka and India, on each occasion after Du Plessis lost the toss in countries where the toss is usually more important than in South Africa.
The transformation target sets out for six players of colour - including two black Africans - to be selected in the South Africa squad. He can be back assertion for a spot into the beginning line-up.
Jofra Archer is expected to be fit again after missing the second Test with an elbow injury and will probably slot back into the England team following the side injury which put James Anderson, England's best bowler at Newlands, out of the tour.
Crowd support: A total of 68,662 spectators created a vibrant atmosphere at Newlands but anecdotal evidence suggests that around 40,000 of them were backing England.
Port Elizabeth features pleasant shores and it is close to online game reserves it is almost in identical league as a drawcard for tourists.