These new guidelines will assist state and local officials to opt to maintain current conditions or "increasing or relaxing social distancing and other mitigation measures".
The announcement of the forthcoming new guidelines comes days after Trump said he hoped to "reopen" the country by Easter.
Trump has said he would like people in parts of the country that have not experienced massive outbreaks to be able to go back to work, perhaps around April 12.
Most of the reductions occurred over the past two years, as part of a large reduction of U.S. -funded health and science experts at the Beijing office of the U.S. Centers for Disease Control and Prevention (CDC).
He did not say when the new guidelines would be issued but he has previously indicated this will be as early as next week when a 15-day period recommending social distancing across the entire country will expire.
When asked about Republican Senator Marco Rubio's statement that WHO displayed "favoritism" towards China, Trump said, "It (WHO) has been very very much sided with China".
"Wouldn't it be great to have all of the churches full?" "I'm very close to them, as you know", Trump said.
Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, who has floated the possibility that a peak number of cases in the US would not arrive until around May 1, appeared to dial back public expectations, saying new federal guidelines would allow for "flexibility in different areas".
"You've got to understand that you don't make the timeline, the virus makes the timeline", Fauci told CNN Wednesday. "So you've got to respond, in what you see happen".
White House counselor Kellyanne Conway said Trump developed the Easter date as a goal to give people "hope".
While the worst outbreaks are concentrated in certain parts of the country, most significantly in NY, experts warn that the highly infectious disease is certain to spread.
Trump said the roll-out of additional testing will enable more nuanced recommendations that would allow some lesser-impacted parts of the country to regain a sense of normalcy sooner.
It remains to be seen how a potential conflict might be resolved, but what is clear is that Trump can not simply force local governments to adopt federal guidelines wholesale.
By removing experts from China, some of them months before the outbreak, the Trump administration apparently made this catastrophe more likely and more hard to respond to, but the president flatly declared that he is "not responsible".
Suderman reported from Richmond, Va.