The Iranian leader repeated the myth that Israel's survival was dependent on external backing, as he denounced the "satanic" US for providing "unconditional, shameless support" alongside those "Arab and Islamic governments refraining from supporting Palestine".
Ayatollah Khamenei noted: "This nation should determine what political system should rule there; struggle must continue until then".
The poster, shared on Khamenei's website, showed people celebrating at the Temple Mount compound in Jerusalem after apparently capturing it from Israel as a Palestinian flag is raised over the Al-Aqsa Mosque.
Due to the coronavirus pandemic, Iran largely asked demonstrators to stay home.
"Khamenei, the Supreme Leader of the #1 state sponsor of antisemitism + terror, is calling for the "final solution" to destroy the Jewish state". He repeatedly referred to Israel as a "cancer" or "tumor" during the speech, criticizing the US and the West for equipping it with "various kinds of military and non-military tools of power, even with atomic weapons".
U.S. President Donald Trump winks at Israel's Prime Minister Benjamin Netanyahu as they discuss a Middle East peace plan proposal during a joint news conference in the East Room of the White House in Washington, U.S., January 28, 2020. The late Palestinian Liberation Organization leader Yasser Arafat was among the first people invited to Iran after the revolution. Mass rallies urging Israel's violent destruction are typically held in Tehran and other Iranian cities, with pro-Iranian groups in London, Berlin, Vienna and other global cities holding demonstrations that display the flag of Hezbollah along with virulently anti-Zionist and antisemitic slogans.
Today, Iran and Israel remain enemies and Israel is believed to be behind airstrikes targeting Iranian forces in Syria.
The text is reminiscent of the "Final Solution of the Jewish Question", a euphemism used by Nazi Germany's leaders referring to the mass murder of world Jewry.
He was responding to comments posted on Twitter by Khamenei on Wednesday in Farsi, English and Arabic.
Iran's foreign minister on Thursday defended an anti-Israel poster shared by the country's leader that invoked the term "final solution", after Israeli and United States leaders accused him of advocating genocide.