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The Duke and Duchess of Sussex will make opening and closing remarks and lead conversations during the session, and will focus on how online communities can be safer and more trustworthy.
The Duchess beams shyly, not looking directly at the camera, as she rests her arm on her husband Harry's leg.
She also gave some advice to people who are building their online brands, noting, "as you are out there engaging with friends online, just be conscious of what you're doing..."
The former actress looks stylish in a black blazer and pants.
'This special episode marks our first collaboration, and we are thrilled to partner with The Duke and Duchess of Sussex to explore these urgent issues'.
Dan Macsai, TIME executive editor and editorial director of the TIME100, added: "The Duke and Duchess of Sussex, both TIME100 alumni, are among the most influential voices in the world". "We look forward to working with them to elevate essential voices and highlight real solutions to some of the most pressing issues of our time".
Meghan Markle visits a London radio station in 2018 | Dominic Lipinski – WPA Pool Getty Images
Remember when Meghan Markle guest edited an entire issue of Vogue UK called "Forces for Change" and it was all extremely cool and impressive and there was literally nothing to complain about?
Most importantly for the royals?
During Fortune's Most Powerful Women Next Gen Virtual Summit on Tuesday, she said, "I have a lot of concerns for people that have become obsessed with it [social media]".
They are living in an £11 million mansion in California with their young son Archie.
"I had a personal account years ago, which I closed down, and then we had one through the institution and our office that was in the United Kingdom that wasn't managed by us -that was a whole team - and so I think that comes with the territory for the job you have", Meghan explained, referencing the SussexRoyal Instagram account she and Prince Harry had before stepping down for their senior royal roles.
Their new careers include a deal with Netflix to make shows for the streaming service.