Premier Doug Ford says the order will take effect at 12:01 a.m. Thursday morning and last for four weeks.
All other non-essential retail stores will go back to curbside pick up.
The measures expected to be announced would go above and beyond restrictions put in place during the first stay-at-home order, which the province implemented January 14 and subsequently extended February 8.
Big-box stores meanwhile will be restricted to essential aisles only - the first time during the pandemic that such a restriction has been imposed.
Move would close all non-essential businesses to in-person shopping, restrict non-essential sections of big box stores. The CBC reported that province-wide school closures were not in the new order.
The province has not closed schools, but local public health chiefs in Toronto, Peel and Wellington-Dufferin-Guelph ordered all schools closed until at least April 19. There were nine confirmed B.1.1.7 variant cases and 466 have screened positive for a variant of concern. The number of COVID-19 hospitalizations in the province has increased by 28.2 per cent between the period of March 28 and April 5, 2021.
The Premier added that anyone calling for paid sick days from the Ford Government is just playing politics as Ottawa already has a program in place.
The province said that it's setting up mobile teams and pop-up clinics to target high-risk congregate settings, residential buildings, faith-based facilities, community centres and locations occupied by large employers in hot spot neighbourhoods.
Ontario residents are waiting to hear if the province will be issuing another stay-at-home order later today.